Tendencias en Investigación Médica

This article reviews a study on the relationship between statin use and the risk of Amyotrophic Lateral Sclerosis (ALS). It found that short-term statin use may increase ALS risk, while long-term use appears to lower it, suggesting reverse causation rather than a protective effect of statins. The...

Reduced Dose-Direct Oral Anticoagulant Vs Dual Antiplatelet Therapy After Left Atrial Appendage Closure in Patients With Nonvalvular Atrial Fibrillation: A Systematic Review and Meta Analysis.

This systematic review and meta-analysis evaluated the efficacy and safety of reduced-dose direct oral anticoagulants (DOACs) compared to dual antiplatelet therapy (DAPT) following left atrial appendage closure (LAAC) in adults with nonvalvular atrial fibrillation (NVAF). Analyzing data from seve...

Antidepressant use and dementia, cognitive measures, and neuroimaging outcomes: A population-based cohort study.

This study investigates the association between baseline antidepressant use and the risk of developing dementia. In a cohort of 461,464 participants, 7.3% reported antidepressant use, with a follow-up revealing that 1.7% developed dementia. The results indicate that baseline antidepressant use is...

Enhancing plasticity to treat depression and other central nervous system diseases using event-driven pharmacology.

This review explores the concept of event-driven pharmacology (EDP) in psychopharmacology, highlighting how plastogens, such as ketamine, can induce long-lasting neural plasticity and metaplasticity. The findings suggest that traditional drug development models may need to adapt to accommodate th...

Health related self efficacy and associated factors among patients with chronic diseases at university of Gondar comprehensive specialize hospital.

This study assessed health-related self-efficacy (HRSE) among 410 patients with chronic diseases at the University of Gondar Comprehensive Specialized Hospital. The findings revealed that only 25.6% of participants had good HRSE, with higher educational levels and comorbidities linked to better o...