CCaS: A New Conceptual Framework in Cerebrovascular Disease.
Pubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedLe pubblicazioni più impattanti della settimana in 29 specialità, curate dall'IA
Ultimo aggiornamento: 28 lug 2026
Pubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
The abstract emphasizes the importance of mentorship and knowledge transfer in stroke medicine, highlighting how mentors pass down their knowledge and experience to mentees. It underscores the significance of cultivating the next generation of leaders in this field, suggesting that this process i...
Leggi su PubMedPubblicato: 2026-07-28
Blood advances
Medical Digest Indicizzato: 2026-07-29
The phase 2 ACE-WM-001 trial assessed acalabrutinib in 106 patients with Waldenström macroglobulinemia, showing overall response rates of 92.9% and 94.6% for treatment-naive and relapsed/refractory cohorts, respectively. Median progression-free survival was not estimable for treatment-naive and 6...
Leggi su PubMedPubblicato: 2026-07-28
Kardiologia polska
Medical Digest Indicizzato: 2026-07-29
This study analyzed 749,235 coronary angiographies from Poland's National Registry of Procedures of Invasive Cardiology database, focusing on trends in non-obstructive coronary artery disease. Findings showed an increase in non-obstructive lesions and a decrease in normal angiograms. Higher body ...
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Blood advances
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Cancer letters
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Cell reports
Medical Digest Indicizzato: 2026-07-29
This study identifies GBP6 as a mitochondrial factor associated with aggressive cervical cancer, enriched in high-risk tumors and correlating with poor clinical outcomes. GBP6 knockdown suppresses tumor cell proliferation and promotes cell death by disrupting mitochondrial bioenergetics and induc...
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Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Medical Digest Indicizzato: 2026-07-29
This study focuses on reprogramming myofibroblastic cancer-associated fibroblasts (CAFs) into immune activated antigen presenting CAFs (apCAFs) as a treatment for fibrotic breast cancer. Using a spatiotemporally ultrasound-controlled nanoparticle, the researchers successfully reprogrammed myCAFs ...
Leggi su PubMedPubblicato: 2026-07-27
Journal for immunotherapy of cancer
Medical Digest Indicizzato: 2026-07-29
This study explores the role of mitophagy in cancer immunogenicity, identifying TOMM40 as a gatekeeper of mitochondrial import that restrains mitophagy. Loss of TOMM40 induces mitochondrial dysfunction and hyperactivated mitophagy, converting immune-cold tumors into immune-inflamed states with in...
Leggi su PubMedPubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-28
Annals of clinical and translational neurology
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Neuropsychologia
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Medical Digest Indicizzato: 2026-07-29
This study identifies the immunoproteasome subunit LMP2 as a key regulator of astrocyte reactivity and neuroinflammatory outcomes following ischemic stroke. Using knockout models, researchers found that LMP2 deficiency reduces infarct volume, attenuates neuroinflammation, and improves neurologica...
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Cancer letters
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Journal of gastrointestinal cancer
Medical Digest Indicizzato: 2026-07-29
This study found that protein-energy malnutrition (PEM) affects one in five hospitalizations among young adults with gastrointestinal cancers. PEM was associated with higher in-hospital mortality, longer hospital stays, and increased hospital charges. Adjusted analyses showed PEM was independentl...
Leggi su PubMedPubblicato: 2026-07-27
Pediatric surgery international
Medical Digest Indicizzato: 2026-07-29
This study evaluated the use of machine learning models to predict 2-year native liver survival (NLS) in biliary atresia (BA) patients following Kasai portoenterostomy (KPE). Data from 154 BA patients were analyzed using traditional machine learning algorithms, with the random forest model showin...
Leggi su PubMedPubblicato: 2026-07-27
Journal of robotic surgery
Medical Digest Indicizzato: 2026-07-28
This bibliometric analysis of 126 papers on robotic cholecystectomy for gallstone disease reveals a growing trend in research output, particularly after 2021. The United States leads in research productivity, with a significant shift in focus from conventional laparoscopic management to robotic s...
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Biomedical physics & engineering express
Medical Digest Indicizzato: 2026-07-28
This study introduces BMSNet, a boundary-guided multi-scale network for accurate polyp segmentation in colonoscopy images. The method uses a Scale-Aware Modulation Meets Transformer-T backbone and includes a boundary prediction module and a boundary-guided feature enhancement module. BMSNet achie...
Leggi su PubMedPubblicato: 2026-12-01
Journal of enzyme inhibition and medicinal chemistry
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Cancer letters
Medical Digest Indicizzato: 2026-07-29
This study highlights the role of neutrophil extracellular traps (NETs) in lung cancer progression, particularly in high-stiffness tumor niches. Using AFM and mIF, the researchers demonstrated a spatial correlation between NETs formation and ECM stiffness, suggesting that targeting NETs could imp...
Leggi su PubMedPubblicato: 2026-07-28
The Pediatric infectious disease journal
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-28
The Pediatric infectious disease journal
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
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The Pediatric infectious disease journal
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-28
Zhonghua yi xue za zhi
Medical Digest Indicizzato: 2026-07-29
(Abstract too short for summarization)
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Zhonghua yi xue za zhi
Medical Digest Indicizzato: 2026-07-29
(Abstract too short for summarization)
Leggi su PubMedPubblicato: 2026-07-28
British journal of clinical pharmacology
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Circulation
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-27
European journal of pediatrics
Medical Digest Indicizzato: 2026-07-29
This study found that normal-weight adolescents with polycystic ovary syndrome (PCOS) have greater visceral adiposity compared to healthy controls, even after adjusting for BMI percentile. Triglycerides and the TG/HDL-C ratio were higher in the PCOS group but should be interpreted cautiously in r...
Leggi su PubMedPubblicato: 2026-07-28
Journal of nephrology
Medical Digest Indicizzato: 2026-07-29
This study assessed the care of dialysis-requiring acute kidney injury (AKI-D) across Italy, revealing that AKI-D accounts for 20% to over 60% of dialysis-unit activity. Kidney replacement therapy is often provided outside nephrology wards, primarily in cardiac ICUs and emergency departments. Con...
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Journal of ultrasound
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Journal of robotic surgery
Medical Digest Indicizzato: 2026-07-28
This umbrella review compared robot-assisted kidney transplantation (RAKT) and open kidney transplantation (OKT) using systematic reviews and meta-analyses. RAKT showed better perioperative outcomes such as reduced blood loss and surgical site infections but open surgery had advantages in certain...
Leggi su PubMedPubblicato: 2026-07-27
Scientific reports
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Journal of clinical anesthesia
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-12-31
Autoimmunity
Medical Digest Indicizzato: 2026-07-27
This study involving 235 patients with systemic lupus erythematosus (SLE) found that lower serum interleukin-2 (IL-2) levels were associated with specific hematological abnormalities, including anemia, leukopenia, and lymphopenia. Using multivariate regression analysis, the study identified signi...
Leggi su PubMedPubblicato: 2026-12-31
Gut microbes
Medical Digest Indicizzato: 2026-07-24
This study highlights the role of gut microbiota dysbiosis and host protein glycosylation in the immune signaling involved in the progression of rheumatoid arthritis (RA).
Leggi su PubMedPubblicato: 2026-08-01
Health science reports
Medical Digest Indicizzato: 2026-07-28
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
The Analyst
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-25
Phytomedicine : international journal of phytotherapy and phytopharmacology
Medical Digest Indicizzato: 2026-07-26
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-12-01
Virulence
Medical Digest Indicizzato: 2026-07-29
This review discusses the formation process of biofilms, mechanisms of antibiotic tolerance and resistance, and new intervention approaches. Biofilms, with their stable structure and protective mechanisms, pose a significant challenge in eradicating clinical infections. The review highlights the ...
Leggi su PubMedPubblicato: 2026-07-28
Zhonghua wai ke za zhi [Chinese journal of surgery]
Medical Digest Indicizzato: 2026-07-29
(Abstract too short for summarization)
Leggi su PubMedPubblicato: 2026-07-27
The Lancet. Infectious diseases
Medical Digest Indicizzato: 2026-07-29
In sub-Saharan Africa, advanced HIV patients hospitalized with high mortality rates often have undiagnosed tuberculosis. Despite concerns about toxicity and drug interactions, short-term empiric antituberculous therapy appears safe and may improve survival in high-risk patients. A paradigm shift ...
Leggi su PubMedPubblicato: 2026-07-27
Current microbiology
Medical Digest Indicizzato: 2026-07-29
This study analyzed 144 E. coli strains to investigate the correlation between phylogenetic groups and antibiotic resistance. Clinical isolates showed high resistance to cephalosporins and fluoroquinolones, while food-derived strains had lower resistance levels. Phylogroup A had the highest preva...
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Current microbiology
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-08-01
EJHaem
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-08-01
Stroke
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-28
The Pediatric infectious disease journal
Medical Digest Indicizzato: 2026-07-29
This study highlights the extensive and heterogeneous use of antifungal agents in pediatric oncology and hematopoietic stem cell transplantation settings, with a heavy reliance on prophylactic and empiric strategies and minimal targeted therapy. The findings underscore the need for structured ant...
Leggi su PubMedPubblicato: 2026-07-28
Zhonghua yi xue za zhi
Medical Digest Indicizzato: 2026-07-29
The incidence of mucormycosis is increasing among patients with hematologic malignancies and those undergoing hematopoietic stem cell transplantation in China. A consensus led by the Mycology Committee of the Chinese Medical Education Association, involving 23 experts, was developed to address th...
Leggi su PubMedPubblicato: 2026-07-28
Blood advances
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-28
Proceedings of the National Academy of Sciences of the United States of America
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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Psychological medicine
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-28
Proceedings of the National Academy of Sciences of the United States of America
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Cognitive neuropsychiatry
Medical Digest Indicizzato: 2026-07-29
This study evaluated cognitive functioning and linguistic measures in patients with schizophrenia, bipolar disorder, and healthy controls. Participants with schizophrenia showed lower verbal production and reduced sentence complexity compared to healthy controls, while those with bipolar disorder...
Leggi su PubMedPubblicato: 2026-07-27
Molecular psychiatry
Medical Digest Indicizzato: 2026-07-29
This study used a transdiagnostic framework to identify early markers of emotion dysregulation (ED) in high-risk populations. A total of 237 participants completed a multimodal assessment. Principal component analysis (PCA) identified eight components, with two significantly differing between gro...
Leggi su PubMedPubblicato: 2026-07-28
Melanoma research
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
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International journal of pharmaceutics
Medical Digest Indicizzato: 2026-07-29
This study developed three curcumin lipid nanoparticles for non-melanoma skin cancer treatment. The nanoparticles showed improved skin penetration and enhanced cytotoxic and phototoxic effects compared to free curcumin. Specifically, A1Cur exhibited a hexagonal liquid-crystalline phase and demons...
Leggi su PubMedPubblicato: 2026-07-27
Journal of cutaneous medicine and surgery
Medical Digest Indicizzato: 2026-07-28
This study evaluated the reporting of race, ethnicity, and skin type in Canadian dermatology RCTs published between 2020 and 2025. Among 99 trials with 36,178 participants, race was reported in 93%, ethnicity in 39%, and Fitzpatrick skin type in 10%. Detailed racial or ethnic categories were pres...
Leggi su PubMedPubblicato: 2026-07-27
Cancer discovery
Medical Digest Indicizzato: 2026-07-28
This study highlights the challenges in advancing oncolytic viruses for cancer treatment, with T-VEC being the first approved and RP1 as the next candidate for melanoma. Issues such as flawed trial designs, mistimed drug combinations, tumor defenses, and delivery challenges have hindered progress...
Leggi su PubMedPubblicato: 2026-07-27
Journal of the American Academy of Dermatology
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-27
Microsystems & nanoengineering
Medical Digest Indicizzato: 2026-07-29
This study introduces a compact, passive glaucoma implant designed to dynamically modulate hydraulic resistance and maintain intraocular pressure within physiological ranges. The implant effectively regulates pressure, mitigates early hypotony, and adapts to increasing downstream resistance. Ex v...
Leggi su PubMedPubblicato: 2026-07-27
American journal of ophthalmology
Medical Digest Indicizzato: 2026-07-29
This study compared corneal-compensated intraocular pressure (IOPcc) with Goldmann applanation tonometry (GAT-IOP) in an elderly cohort. Using data from the Thessaloniki Eye Study, it found that IOPcc was on average 2.75 mmHg higher than GAT-IOP. The prevalence of ocular hypertension increased fr...
Leggi su PubMedPubblicato: 2026-07-27
Ophthalmology and therapy
Medical Digest Indicizzato: 2026-07-29
This retrospective cohort study evaluated the 12-month outcomes of faricimab treatment for polypoidal choroidal vasculopathy (PCV) in a multi-ethnic cohort. In treatment-naïve eyes, visual acuity improved by +6.8 letters (P < 0.01) and CST reduced by -54 µm (P < 0.01). In treatment-experienced ey...
Leggi su PubMedPubblicato: 2026-07-27
Archivos de la Sociedad Espanola de Oftalmologia
Medical Digest Indicizzato: 2026-07-29
This prospective study evaluated the efficacy and safety of PRESERFLO® implantation combined with 0.04% MMC and DuraGen® in 50 eyes with moderate or severe glaucoma. The mean preoperative intraocular pressure (IOP) was 26.8 ± 7.1 mmHg, which decreased to 13.1 ± 4.5 mmHg, a reduction of 47.9% (p <...
Leggi su PubMedPubblicato: 2026-07-27
Retina (Philadelphia, Pa.)
Medical Digest Indicizzato: 2026-07-29
This study involving 40,078 participants from the UK Biobank aimed to determine if specific pre-diagnostic macular thickness patterns are linked to an increased risk of age-related macular degeneration (AMD). Using optical coherence tomography (OCT) imaging, two distinct macular thickness profile...
Leggi su PubMedPubblicato: 2026-07-28
Current opinion in pediatrics
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-28
Circulation
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Infection
Medical Digest Indicizzato: 2026-07-29
This study evaluated the effectiveness of maternal aP vaccination in preventing pertussis in infants during an outbreak in Thailand. The case-control study included 33 symptomatic cases and 330 asymptomatic controls. Results showed that maternal vaccination significantly reduced the risk of pertu...
Leggi su PubMedPubblicato: 2026-07-27
Cardiology in the young
Medical Digest Indicizzato: 2026-07-28
This study evaluated Post-intensive Care Syndrome in Paediatrics in CHD patients aged 5-18 years with at least one cardiac ICU admission. Using physical, cognitive, social, and emotional questionnaires, 80% of the 117 patients were found to have the syndrome, with 36% physical, 70% cognitive, 26%...
Leggi su PubMedPubblicato: 2026-07-27
Journal of pediatric endocrinology & metabolism : JPEM
Medical Digest Indicizzato: 2026-07-28
This retrospective cohort study of 162 pediatric patients with diabetic ketoacidosis (DKA) found that hyperchloremia, present in 81.5% of patients, is associated with longer DKA resolution time, slower bicarbonate rise, and longer PICU stay. Hyperchloremia was predicted by lower body weight and t...
Leggi su PubMedPubblicato: 2026-08-01
The journal of trauma and acute care surgery
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-08-01
Health science reports
Medical Digest Indicizzato: 2026-07-28
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-28
The American surgeon
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Clinical and experimental emergency medicine
Medical Digest Indicizzato: 2026-07-29
This scoping review aimed to explore existing evidence on peer-led CPR training across various populations and settings. A total of 37 studies were included, identifying four peer-training models. The review found that peer-led training often achieved similar educational outcomes to professional ...
Leggi su PubMedPubblicato: 2026-07-27
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
Medical Digest Indicizzato: 2026-07-29
This systematic review evaluated management strategies for neglected traumatic hip dislocation (NTHD), focusing on functional outcomes and complications. Twenty-one studies with 200 patients were analyzed. Open reduction is viable for dislocations less than 3 months, while THA is most reliable fo...
Leggi su PubMedPubblicato: 2026-07-28
Zhonghua yi xue za zhi
Medical Digest Indicizzato: 2026-07-29
(Abstract too short for summarization)
Leggi su PubMedPubblicato: 2026-07-27
Journal of surgical education
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Polish archives of internal medicine
Medical Digest Indicizzato: 2026-07-29
(No abstract provided)
Leggi su PubMedPubblicato: 2026-07-27
JHEP reports : innovation in hepatology
Medical Digest Indicizzato: 2026-07-29
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-07-27
Journal of neural engineering
Medical Digest Indicizzato: 2026-07-28
(No abstract provided)
Leggi su PubMedPubblicato: 2026-12-31
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Medical Digest Indicizzato: 2026-07-24
This study highlights the significant rise in female infertility globally, with cases increasing by 84.4% from 1990 to 2021, reaching 110.09 million. The age-standardized prevalence rate is also on the rise, particularly in high SDI regions, which show the fastest growth. Projections indicate tha...
Leggi su PubMedPubblicato: 2026-12-01
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Medical Digest Indicizzato: 2026-07-25
This study investigates the predictive value of ultrasound measures in patients with placenta accreta spectrum (PAS) for adverse pregnancy outcomes (APOs). Among 180 women with PAS, 42.22% experienced complications. The study found that those with complications exhibited higher placental blood fl...
Leggi su PubMedPubblicato: 2026-12-01
Annals of medicine
Medical Digest Indicizzato: 2026-07-26
This retrospective study of 9372 GnRH antagonist cycles found that gonadotropin stimulation duration is associated with oocyte maturation and pregnancy outcomes, even after adjusting for confounders. The optimal duration for achieving the highest likelihood of clinical pregnancy and live birth is...
Leggi su PubMedPubblicato: 2026-12-01
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Medical Digest Indicizzato: 2026-07-26
(Summary generation failed. Please refer to the original article.)
Leggi su PubMedPubblicato: 2026-08-01
Clinical case reports
Medical Digest Indicizzato: 2026-07-25
Acardiac twinning, or TRAP sequence, is a rare condition in monochorionic twins characterized by severe malformation of one twin due to abnormal placental blood flow. In a case study of a 30-year-old woman, an acephalus acardiac twin was diagnosed during the second trimester. The prognosis for th...
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