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This week's highest-impact publications across 29 specialties, curated by AI

Last updated: 13 de jul. de 2026

Dermatology5 articles

Impact 2

Efficacy and drug survival after transitioning to IL-17 inhibitors in patients with psoriasis who did not respond to IL-23 inhibitors: analysis from the BIOREP registry.

Published: 2026-12-01

The Journal of dermatological treatment

Medical Digest Indexed: 2026-07-11

This study analyzed the efficacy of switching from IL-23 inhibitors to IL-17 inhibitors in psoriasis patients. Out of 102 patients, 90.2% switched due to insufficient efficacy of IL-23 inhibitors. After 3 months, 82.6% achieved PASI-75, and 66.3% reached an absolute PASI ≤ 1. The overall survival...

Read on PubMed
Impact 2

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization.

Published: 2026-09-01

International journal of molecular medicine

Medical Digest Indexed: 2026-07-11

This study highlights the role of metabolic dysregulation, particularly phenylalanine accumulation, in psoriasis pathogenesis. It demonstrates that a high-phenylalanine diet worsens skin inflammation, while dietary restriction or L-type amino acid transporter inhibitors can alleviate it. The find...

Read on PubMed
Impact 3

Prognostic Factors in Primary Head and Neck Cutaneous Squamous Cell Carcinoma: A Large-Scale, Multi-Institutional Competing-Risks Analysis.

Published: 2026-07-12

Journal of surgical oncology

Medical Digest Indexed: 2026-07-14

This study analyzed data from 8,610 patients with head and neck cutaneous squamous cell carcinoma to identify independent prognostic factors. Key findings include that tumor diameter, poor differentiation, deep invasion, and large-caliber perineural invasion are critical predictors of outcomes. A...

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Impact 2

Cross-Sectional Survey of Unmet Needs in Children With NF1 and Cutaneous Neurofibromas: The Role of Pediatric Dermatology.

Published: 2026-07-12

Pediatric dermatology

Medical Digest Indexed: 2026-07-14

This study assessed pediatric dermatologists' roles and barriers in treating neurofibromatosis type 1 (NF1) through a survey of 131 respondents. It found that while these specialists are engaged in diagnosis and follow-up, they are underrepresented in multidisciplinary clinics, with surgical exci...

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Impact 2

Selective Depletion of Tumor-Infiltrating CD4

Published: 2026-07-12

Cancer science

Medical Digest Indexed: 2026-07-14

This study highlights the role of regulatory T cells in ovarian cancer and the challenges in developing strategies to target these cells effectively.

Read on PubMed

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