Name: Medical Digest
Author: Medical Digest

皮肤科5 篇

影响力 2

Efficacy and drug survival after transitioning to IL-17 inhibitors in patients with psoriasis who did not respond to IL-23 inhibitors: analysis from the BIOREP registry.

发表日期: 2026-12-01

The Journal of dermatological treatment

Medical Digest 收录日: 2026-07-11

This study analyzed the efficacy of switching from IL-23 inhibitors to IL-17 inhibitors in psoriasis patients. Out of 102 patients, 90.2% switched due to insufficient efficacy of IL-23 inhibitors. After 3 months, 82.6% achieved PASI-75, and 66.3% reached an absolute PASI ≤ 1. The overall survival...

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影响力 2

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization.

发表日期: 2026-09-01

International journal of molecular medicine

Medical Digest 收录日: 2026-07-11

This study highlights the role of metabolic dysregulation, particularly phenylalanine accumulation, in psoriasis pathogenesis. It demonstrates that a high-phenylalanine diet worsens skin inflammation, while dietary restriction or L-type amino acid transporter inhibitors can alleviate it. The find...

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影响力 3

Prognostic Factors in Primary Head and Neck Cutaneous Squamous Cell Carcinoma: A Large-Scale, Multi-Institutional Competing-Risks Analysis.

发表日期: 2026-07-12

Journal of surgical oncology

Medical Digest 收录日: 2026-07-14

This study analyzed data from 8,610 patients with head and neck cutaneous squamous cell carcinoma to identify independent prognostic factors. Key findings include that tumor diameter, poor differentiation, deep invasion, and large-caliber perineural invasion are critical predictors of outcomes. A...

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影响力 2

Cross-Sectional Survey of Unmet Needs in Children With NF1 and Cutaneous Neurofibromas: The Role of Pediatric Dermatology.

发表日期: 2026-07-12

Pediatric dermatology

Medical Digest 收录日: 2026-07-14

This study assessed pediatric dermatologists' roles and barriers in treating neurofibromatosis type 1 (NF1) through a survey of 131 respondents. It found that while these specialists are engaged in diagnosis and follow-up, they are underrepresented in multidisciplinary clinics, with surgical exci...

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影响力 2

Selective Depletion of Tumor-Infiltrating CD4

发表日期: 2026-07-12

Cancer science

Medical Digest 收录日: 2026-07-14

This study highlights the role of regulatory T cells in ovarian cancer and the challenges in developing strategies to target these cells effectively.

在PubMed上阅读

医学研究趋势

皮肤科5 篇

Efficacy and drug survival after transitioning to IL-17 inhibitors in patients with psoriasis who did not respond to IL-23 inhibitors: analysis from the BIOREP registry.

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization.

Prognostic Factors in Primary Head and Neck Cutaneous Squamous Cell Carcinoma: A Large-Scale, Multi-Institutional Competing-Risks Analysis.

Cross-Sectional Survey of Unmet Needs in Children With NF1 and Cutaneous Neurofibromas: The Role of Pediatric Dermatology.

Selective Depletion of Tumor-Infiltrating CD4

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